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Nattokinase/Drug Interactions:- Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Research from in vitro and in vivo trials suggests that natto and nattokinase possess thrombolytic activity (1; 6; 2; 7; 8; 5). However, some natto and some nattokinase supplements reportedly contain vitamin K (between 0.5 and 2.6mcg/g), which can antagonize the effects of anticoagulants like warfarin, according to secondary sources.
- AntihypertensivesAntihypertensives: In clinical study, decreases in systolic (9; 10; 11) and diastolic blood pressure (9) have been observed after treatment with nattokinase. Theoretically, concurrent use of nattokinase and antihypertensives may have additive blood pressure-lowering effects and increase the risk of hypotension.
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Nattokinase/Herb/Supplement Interactions:- Anticoagulants and antiplateletsAnticoagulants and antiplatelets: Research from in vitro and in vivo trials suggests that natto and nattokinase possess thrombolytic activity (1; 6; 2; 7; 8; 5). However, some natto and some nattokinase supplements reportedly contain vitamin K (between 0.5 and 2.6mcg/g), which can antagonize the effects of anticoagulants like warfarin, according to secondary sources.
- HypotensivesHypotensives: In clinical study, decreases in systolic (9; 10; 11) and diastolic blood pressure (9) have been observed after treatment with nattokinase. Theoretically, concurrent use of nattokinase and antihypertensives may have additive blood pressure-lowering effects and increase the risk of hypotension.
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Nattokinase/Food Interactions:- Insufficient available evidence.
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Nattokinase/Lab Interactions:- Blood pressureBlood pressure: In clinical study, decreases in systolic (9; 10; 11) and diastolic blood pressure (9) have been observed after treatment with nattokinase.
- Coagulation panelCoagulation panel: Research from in vitro and in vivo trials suggests that natto and nattokinase possess thrombolytic activity (1; 6; 2; 7; 8; 5). However, some natto and some nattokinase supplements reportedly contain vitamin K (between 0.5 and 2.6mcg/g), which can antagonize the effects of anticoagulants like warfarin. Evidence from in vitro and in vivo trials suggests that natto and nattokinase may affect soluble plasma fibrinogen (1).
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Copyright © 2011 Natural Standard (www.naturalstandard.com)
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The information in this monograph is intended for informational purposes only, and is meant to help users better understand health concerns. Information is based on review of scientific research data, historical practice patterns, and clinical experience. This information should not be interpreted as specific medical advice. Users should consult with a qualified healthcare provider for specific questions regarding therapies, diagnosis and/or health conditions, prior to making therapeutic decisions.
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